BioMarin也迅速跟进迭代研发，其升级版在研产品BMN333同样旨在实现周剂注射。早期临床结果显示BMN333的AUC水平高于其他长效CNP研究的3倍以上，公司研发主管Greg Friberg表示该药对标的正是TransCon-CNP。
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Dithering in its simplest form can be understood by observing what happens when we quantise an image with and without modifying the source by random perturbation. In the examples below, a gradient of 256 grey levels is quantised to just black and white. Note how the dithered gradient is able to simulate a smooth transition from start to end.